通过特定模式的神经冲动控制髓鞘形成。
Control of myelination by specific patterns of neural impulses.
作者信息
Stevens B, Tanner S, Fields R D
机构信息
National Institute of Child Health and Human Development, Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
J Neurosci. 1998 Nov 15;18(22):9303-11. doi: 10.1523/JNEUROSCI.18-22-09303.1998.
Abstract
A cell culture preparation equipped with stimulating electrodes was used to investigate whether action potential activity can influence myelination of mouse dorsal root ganglia axons by Schwann cells. Myelination was reduced to one-third of normal by low-frequency impulse activity (0.1 Hz), but higher-frequency stimulation (1 Hz) had no effect. The number of Schwann cells and the ultrastructure of compact myelin were not affected. The frequency of stimulation that inhibited myelination decreased expression of the cell adhesion molecule L1, and stimulation under conditions that prevented the reduction in L1 blocked the effects on myelination. This link between myelination and functional activity in the axon at specific frequencies that change axonal expression of L1 could have important consequences for the structural and functional relationship of myelinating axons.
摘要
使用配备刺激电极的细胞培养制剂来研究动作电位活动是否会影响雪旺细胞对小鼠背根神经节轴突的髓鞘形成。低频脉冲活动（0.1赫兹）使髓鞘形成减少至正常的三分之一，但高频刺激（1赫兹）则没有影响。雪旺细胞的数量和致密髓鞘的超微结构未受影响。抑制髓鞘形成的刺激频率降低了细胞粘附分子L1的表达，而在防止L1减少的条件下进行刺激则阻断了对髓鞘形成的影响。在特定频率下，髓鞘形成与轴突功能活动之间的这种联系改变了轴突L1的表达，这可能对有髓轴突的结构和功能关系产生重要影响。
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