Liao R M, Chang Y H, Wang S H
Department of Psychology, National Cheng-Chi University, Taipei, Taiwan, ROC.
Chin J Physiol. 1998 Jun 30;41(2):85-92.
The present study investigated the effects of selective dopamine D1 and D2 receptor antagonists, SCH23390 and spiperone, on the expression of conditioned place preference (CPP) induced by either d-amphetamine or cocaine. The CPP protocol consisted of three phases: pre-conditioning exploration, conditioning, and a post-conditioning test. The data indicated that CPP was significantly induced by intraperitoneal injection of either d-amphetamine (2 mg/kg) or cocaine (10 mg/kg). The expression of d-amphetamine CPP was significantly inhibited by SCH23390 (0.08, 0.16 mg/kg) and spiperone (0.15 mg/kg) when given alone before the post-conditioning test session. In contrast, such pretreatment to produce antagonistic effects was not observed for cocaine CPP. However, the expression of cocaine CPP was significantly attenuated by a combination of SCH23390 and spiperone administered prior to the test session. These data indicate that the rewarding properties of d-amphetamine and cocaine as expressed under the CPP task may depend upon different neural substrates. The degrees of D1 and D2 receptors involved in mediating the expression of CPP induced by d-amphetamine and cocaine are different.
本研究调查了选择性多巴胺D1和D2受体拮抗剂SCH23390和舒必利对由右旋苯丙胺或可卡因诱导的条件性位置偏爱（CPP）表达的影响。CPP实验方案包括三个阶段：预处理探索、条件化和后处理测试。数据表明，腹腔注射右旋苯丙胺（2mg/kg）或可卡因（10mg/kg）均能显著诱导CPP。在进行后处理测试前单独给予SCH23390（0.08、0.16mg/kg）和舒必利（0.15mg/kg）时，右旋苯丙胺诱导的CPP表达受到显著抑制。相比之下，未观察到对可卡因诱导的CPP进行此类预处理产生拮抗作用。然而，在测试前联合给予SCH23390和舒必利可显著减弱可卡因诱导的CPP表达。这些数据表明，在CPP任务中表现出的右旋苯丙胺和可卡因的奖赏特性可能取决于不同的神经基质。参与介导右旋苯丙胺和可卡因诱导的CPP表达的D1和D2受体程度不同。
