细粒棘球绦虫感染免疫学的新视角。

New perspectives in the immunology of Echinococcus granulosus infection.

作者信息

Riganò R, Profumo E, Siracusano A

机构信息

Laboratorio di Immunologia, Istituto Superiore di Sanità, Roma, Italy.

出版信息

Parassitologia. 1997 Dec;39(4):275-7.

PMID:9802079

Abstract

This article reviews the role of cytokines and immunoglobulin isotypes in the clinical outcome of E. granulosus infection. The coexistence of elevated quantities of IFN-gamma, IL-4, IL-5, IL-6 and IL-10 observed in most of hydatid patients supports Th1 and Th2 cell activation in human hydatidosis. In particular, Th1 cell activation seems to be related to protective immunity, Th2 cell activation to susceptibility to disease. Analysis of immunoglobulin isotypes expression reveals that the percentage of IgE responses decreases in patients parallelling to their response to chemotherapy and, among the IgG isotypes, only IgG3 and IgG4 appear related to therapy.

摘要

本文综述了细胞因子和免疫球蛋白同种型在细粒棘球绦虫感染临床结局中的作用。在大多数包虫病患者中观察到的大量干扰素-γ、白细胞介素-4、白细胞介素-5、白细胞介素-6和白细胞介素-10的共存支持了人类包虫病中Th1和Th2细胞的激活。特别是，Th1细胞激活似乎与保护性免疫有关，Th2细胞激活与疾病易感性有关。免疫球蛋白同种型表达分析显示，患者体内IgE反应的百分比随着对化疗的反应而降低，在IgG同种型中，只有IgG3和IgG4似乎与治疗有关。