Roeloffzen W W, Verhaegh J J, van Poelgeest A E, Gansevoort R T
Department of Internal Medicine, Twenteborg Hospital, Almelo, The Netherlands.
Neth J Med. 1998 Sep;53(3):113-7. doi: 10.1016/s0300-2977(98)00065-5.
We describe two patients who developed granulocytopenia (granulocyte count < 1.0 x 10(9)/1) after treatment with antithyroid drugs. Although, perhaps, an already known side-effect of these drugs, we present these cases in order to stay alert for this serious complication. The first patient developed granulocytopenia upon reinstitution of propylthiouracil after an uncomplicated first course of ATD-treatment. In the second case we report the use of granulocyte colony-stimulating factor (G-CSF) for treatment of a patient with methimazole-induced granulocytopenia. Furthermore, we discuss current concepts concerning pathophysiology, prevention and therapy.
我们描述了两名在接受抗甲状腺药物治疗后出现粒细胞减少症（粒细胞计数<1.0×10⁹/L）的患者。尽管这可能是这些药物已知的副作用，但我们呈现这些病例是为了对这种严重并发症保持警惕。第一名患者在抗甲状腺药物治疗的第一个疗程无并发症后重新使用丙硫氧嘧啶时出现了粒细胞减少症。在第二个病例中，我们报告了使用粒细胞集落刺激因子（G-CSF）治疗一名因甲巯咪唑引起粒细胞减少症的患者。此外，我们还讨论了有关病理生理学、预防和治疗的当前概念。
