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[腔隙性梗死与深部脑出血:危险因素比较]

[Lacunar infarct and deep cerebral hemorrhage: a comparison of the risk factors].

作者信息

Beltrán I, Lago A, Tembl J I, Landete L, Geffner D

机构信息

Servicio de Neurología, Hospital Universitario La Fe, Valencia.

出版信息

Rev Neurol. 1998 Oct;27(158):635-9.

PMID:9803513
Abstract

INTRODUCTION

Lacunar infarcts (LI) and deep cerebral hemorrhages (DCH) have the same localization and a vasculopathy which appears to be similar, at the level of the small perforating arteries, classically attributed to arterial hypertension (AHT).

OBJECTIVES

To compare the vascular risk factors of patients with lacunar ictus (LIc) and those with DCH, to try to determine how these may affect the appearance of one type of stroke or another.

PATIENTS AND METHODS

We analyzed a prospective consecutive series of patients with cerebral vascular accidents (CVA), selecting 1,540 patients in the first 1,155 with a first CVA. We recorded demographic data and the following risk factors: previous transient ischemic accident (TIA), AHT, diabetes mellitus (DM), hypercholesterolemia, ischemic cardiopathy, atrial fibrillation and the presence of silent infarcts on CT.

RESULTS

Two hundred and four patients had LIc and 163 had DCH. There was a significant dissociation between LIc and a history of TIA, DM, hypercholesterolemia and the presence of silent lacunar-type infarcts on CT. However, after multivariant analysis, DM did not continue to be an independent variable. Arterial blood pressure was found to be greater in the DCH group.

CONCLUSIONS

The presence of different risk factors for LIc and DCH may be the key to understanding the mechanism which leads to one type or other of CVA.

摘要

引言

腔隙性梗死(LI)和深部脑出血(DCH)具有相同的定位,并且在小穿支动脉水平上存在一种似乎相似的血管病变,传统上归因于动脉高血压(AHT)。

目的

比较腔隙性卒中(LIc)患者和DCH患者的血管危险因素,试图确定这些因素如何影响一种或另一种类型的卒中发生。

患者和方法

我们分析了一系列连续性前瞻性脑血管意外(CVA)患者,在最初的1155例首次发生CVA的患者中选取了1540例。我们记录了人口统计学数据以及以下危险因素:既往短暂性脑缺血发作(TIA)、AHT、糖尿病(DM)、高胆固醇血症、缺血性心脏病、心房颤动以及CT上有无无症状性梗死。

结果

204例患者患有LIc,163例患有DCH。LIc与TIA病史、DM、高胆固醇血症以及CT上无症状性腔隙性梗死的存在之间存在显著差异。然而,经过多变量分析后,DM不再是一个独立变量。发现DCH组的动脉血压更高。

结论

LIc和DCH存在不同的危险因素可能是理解导致一种或另一种类型CVA机制的关键。

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