Decristoforo C, Obendorf D, Reichart E, Stubauer G, Riccabona G
University of Klinik Für Nuklearmedizin, Innsbruck, Austria.
Nucl Med Biol. 1998 Oct;25(7):675-83. doi: 10.1016/s0969-8051(98)00024-9.
A novel approach for the determination of the stannous content in cold kits for labelling with 99mTc is described. The method is based on differential pulse polarography on the hanging mercury drop electrode in a methanol/water/perchloric acid mixture and is easy to perform. Examples for the determination of tin(II) in fractionated technetium cold kits are shown. The stability of tin(II) in solution was mainly dependent on the storage temperature and the kit composition. The low stability of stannous ions under certain conditions was shown to be the main reason for low radiochemical purity. Limits and dangers of fractionating kits are discussed and related to content and instability of tin(II).
本文描述了一种测定用于99mTc标记的冷试剂盒中亚锡含量的新方法。该方法基于在甲醇/水/高氯酸混合物中的悬汞滴电极上进行差分脉冲极谱法，操作简便。文中给出了分馏锝冷试剂盒中锡（II）测定的示例。溶液中锡（II）的稳定性主要取决于储存温度和试剂盒组成。结果表明，在某些条件下亚锡离子的低稳定性是放射化学纯度低的主要原因。讨论了分馏试剂盒的局限性和风险，并与锡（II）的含量和不稳定性相关。
