Hardy J, Gwinn-Hardy K
Department of Pharmacology, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
Science. 1998 Nov 6;282(5391):1075-9. doi: 10.1126/science.282.5391.1075.
Review During the past 10 years (the "decade of the brain"), some of the genetic causes of many of the primary neurodegenerative diseases, which include Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, prion disease, and many ataxic syndromes, have been found. These breakthroughs mean that for many of these diseases we now know the initiating trigger as well as the final outcome. These diseases have many pathological mechanisms in common, and there may be relatively few pathways to neuronal death seen in these disorders. Thus, treatment strategies developed for a particular disease may be found to have efficacy in more than one disorder.
综述 在过去的十年（“脑的十年”）中，已发现包括阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化症、朊病毒病及多种共济失调综合征在内的许多原发性神经退行性疾病的一些遗传病因。这些突破意味着对于其中许多疾病，我们现在既了解起始触发因素，也知晓最终结局。这些疾病有许多共同的病理机制，在这些病症中可能仅有相对较少的神经元死亡途径。因此，为某一特定疾病研发的治疗策略可能在不止一种病症中具有疗效。
