Li Zai-Yu, Gao Dan-Yang, Wu Zhi-Yong, Zhao Shuang
Chemistry Department, College of Sciences, Northeastern University Wenhua Road 3-11 Shenyang 110819 Liaoning China
Research Center for Analytical Sciences, Chemistry Department, College of Sciences, Northeastern University Wenhua Road 3-11 Shenyang 110819 Liaoning China
RSC Adv. 2020 Apr 7;10(24):14218-14224. doi: 10.1039/d0ra00290a. eCollection 2020 Apr 6.
Herein multi-walled carbon nanotubes (MWCNTs) were processed by ultrasonication and freeze-drying method. The morphology of the processed MWCNTs was examined by scanning electron microscopy. An original electrochemical sensor for the simultaneous detection of levodapa (LD), paracetamol (PA) and l-tyrosine (Tyr) was developed by dropcasting a mixture of processed MWCNTs and Nafion on a glassy carbon electrode. The as-prepared sensor was studied by cyclic voltammetry and differential pulse voltammetry. The peak currents of LD, PA and Tyr significantly increased compared to those obtained at bare glassy carbon electrodes or unprocessed MWCNTs modified electrodes. The peaks of LD, PA and Tyr were well-defined and obviously separated from each other. The linear ranges for detection of LD, PA and Tyr were 2.0-300.0, 2.0-180.0, and 2.0-120.0 μM, with a detection limit of 0.6, 0.5 and 0.8 μM (S/N = 3), respectively. Finally, the sensor was applied to detect LD, PA and Tyr in serum samples, and the results were satisfactory.
本文采用超声处理和冷冻干燥法对多壁碳纳米管（MWCNTs）进行处理。通过扫描电子显微镜对处理后的MWCNTs的形态进行了检测。通过将处理后的MWCNTs和Nafion的混合物滴铸在玻碳电极上，开发了一种用于同时检测左旋多巴（LD）、对乙酰氨基酚（PA）和L-酪氨酸（Tyr）的新型电化学传感器。采用循环伏安法和差分脉冲伏安法对所制备的传感器进行了研究。与在裸玻碳电极或未处理的MWCNTs修饰电极上获得的峰电流相比，LD、PA和Tyr的峰电流显著增加。LD、PA和Tyr的峰形良好，且彼此明显分离。LD、PA和Tyr的检测线性范围分别为2.0 - 300.0、2.0 - 180.0和2.0 - 120.0 μM，检测限分别为0.6、0.5和0.8 μM（S/N = 3）。最后，将该传感器应用于血清样品中LD、PA和Tyr的检测，结果令人满意。
