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纳米碳材料在药物应用中的最新进展:综述

Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review.

机构信息

Nanotechnology Engineering, Faculty of Advanced Technology and Multidiscipline, Kampus C Universitas Airlangga, Surabaya 60115, Indonesia.

Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia.

出版信息

Molecules. 2022 Nov 4;27(21):7578. doi: 10.3390/molecules27217578.

Abstract

Carbon nanomaterials have attracted researchers in pharmaceutical applications due to their outstanding properties and flexible dimensional structures. Carbon nanomaterials (CNMs) have electrical properties, high thermal surface area, and high cellular internalization, making them suitable for drug and gene delivery, antioxidants, bioimaging, biosensing, and tissue engineering applications. There are various types of carbon nanomaterials including graphene, carbon nanotubes, fullerenes, nanodiamond, quantum dots and many more that have interesting applications in the future. The functionalization of the carbon nanomaterial surface could modify its chemical and physical properties, as well as improve drug loading capacity, biocompatibility, suppress immune response and have the ability to direct drug delivery to the targeted site. Carbon nanomaterials could also be fabricated into composites with proteins and drugs to reduce toxicity and increase effectiveness in the pharmaceutical field. Thus, carbon nanomaterials are very effective for applications in pharmaceutical or biomedical systems. This review will demonstrate the extraordinary properties of nanocarbon materials that can be used in pharmaceutical applications.

摘要

碳纳米材料因其出色的性能和灵活的维度结构,引起了制药应用领域研究人员的关注。碳纳米材料(CNMs)具有导电性、高热表面积和高细胞内化能力,非常适合用于药物和基因传递、抗氧化剂、生物成像、生物传感和组织工程应用。有多种类型的碳纳米材料,包括石墨烯、碳纳米管、富勒烯、纳米金刚石、量子点等,它们在未来具有有趣的应用前景。碳纳米材料表面的功能化可以改变其化学和物理性质,提高药物载药量、生物相容性、抑制免疫反应,并具有将药物靶向递送至目标部位的能力。碳纳米材料还可以与蛋白质和药物复合,以降低毒性并提高在制药领域的效果。因此,碳纳米材料在制药或生物医学系统中的应用非常有效。本综述将展示可用于制药应用的纳米碳材料的非凡特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9822/9654677/9adf2101b91e/molecules-27-07578-sch001.jpg

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