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Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis.

作者信息

Miller C, Degenhardt K, Sassoon D A

出版信息

Nat Genet. 1998 Nov;20(3):228-30. doi: 10.1038/3027.

DOI:10.1038/3027
PMID:9806537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4751032/
Abstract
摘要

相似文献

1
Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis.胎儿在子宫形态发生过程中接触己烯雌酚会导致Wnt7a失调。
Nat Genet. 1998 Nov;20(3):228-30. doi: 10.1038/3027.
2
Developmental diethylstilbestrol exposure alters genetic pathways of uterine cytodifferentiation.发育期接触己烯雌酚会改变子宫细胞分化的遗传途径。
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3
Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth.Wnt7a是女性生殖道细胞死亡的抑制因子，是出生后生长和雌激素介导的生长所必需的。
Biol Reprod. 2004 Aug;71(2):444-54. doi: 10.1095/biolreprod.103.026534. Epub 2004 Apr 7.
4
Endosulfan affects uterine development and functional differentiation by disrupting Wnt7a and β-catenin expression in rats.硫丹通过干扰大鼠体内Wnt7a和β-连环蛋白的表达来影响子宫发育和功能分化。
Mol Cell Endocrinol. 2016 Apr 15;425:37-47. doi: 10.1016/j.mce.2016.02.011. Epub 2016 Feb 18.
5
Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats.确定艾克大鼠发育编程中增加子宫平滑肌瘤风险的敏感期。
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6
Expression of estrogen-regulated genes during development in the mouse uterus exposed to diethylstilbestrol neonatally.新生期暴露于己烯雌酚的小鼠子宫发育过程中雌激素调节基因的表达
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Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract.雌激素受体α基因敲除小鼠对新生期暴露于己烯雌酚对雌性生殖道的发育影响具有抗性。
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Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus.在发育过程中接触己烯雌酚会引发小鼠子宫中雌激素反应性乳铁蛋白基因的去甲基化。
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Invited comment: "Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats".特邀评论：“确定埃克尔大鼠发育编程中增加子宫平滑肌瘤风险的敏感期”。
Reprod Sci. 2007 Feb;14(2):99-100. doi: 10.1177/1933719107300290.

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Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol.同源结构域转录因子Msx-2调节子宫祖细胞对己烯雌酚的反应。
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Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells.新生雌二醇暴露改变了子宫上皮细胞的代谢特征。
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CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus.CDH1 对于小鼠子宫内的子宫内膜分化、腺体发育和成年功能是必需的。
Biol Reprod. 2012 May 3;86(5):141, 1-10. doi: 10.1095/biolreprod.112.098871. Print 2012 May.
10
Dynamic regulation of Wnt7a expression in the primate endometrium: implications for postmenstrual regeneration and secretory transformation.Wnt7a 在灵长类动物子宫内膜中的动态调控：对月经后再生和分泌转化的影响。
Endocrinology. 2012 Mar;153(3):1063-9. doi: 10.1210/en.2011-1826. Epub 2012 Jan 31.

本文引用的文献

1
Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract.在小鼠雌性生殖道发育过程中，Wnt-7a维持适当的子宫模式。
Development. 1998 Aug;125(16):3201-11. doi: 10.1242/dev.125.16.3201.
2
Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol.子宫内暴露于己烯雌酚的后代的上生殖道变化及妊娠结局
Am J Obstet Gynecol. 1980 Jun 1;137(3):299-308. doi: 10.1016/0002-9378(80)90913-8.
3
Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol.产前暴露于己烯雌酚对雌性小鼠生殖道的长期影响。
Cancer Res. 1980 Nov;40(11):3988-99.
4
Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbestrol.在出生前或出生后接触己烯雌酚的小鼠中的阴道腺病和腺癌。
Cancer Res. 1982 May;42(5):2003-11.
5
Diethylstilbestrol in pregnancy. Frequency of exposure and usage patterns.孕期己烯雌酚。暴露频率及使用模式。
Cancer. 1973 Mar;31(3):573-7. doi: 10.1002/1097-0142(197303)31:3<573::aid-cncr2820310312>3.0.co;2-#.
6
Risk factors for the development of diethylstilbestrol-associated clear cell adenocarcinoma: a case-control study.己烯雌酚相关透明细胞腺癌发生的危险因素：一项病例对照研究。
Am J Obstet Gynecol. 1986 Apr;154(4):814-22. doi: 10.1016/0002-9378(86)90464-3.
7
Development of vaginal adenosis-like lesions and uterine epithelial stratification in mice exposed perinatally to diethylstilbestrol.围产期暴露于己烯雌酚的小鼠阴道腺病样病变和子宫上皮分层的发育。
Proc Soc Exp Biol Med. 1986 Jan;181(1):59-65. doi: 10.3181/00379727-181-42224.
8
Postnatal development of uterine abnormalities in mice exposed to DES in utero.子宫内暴露于己烯雌酚的小鼠产后子宫异常的发育
Biol Neonate. 1987;52(2):97-103. doi: 10.1159/000242690.
9
Colposcopic findings in offspring of DES-treated mothers as related to onset of therapy.己烯雌酚治疗的母亲所生后代的阴道镜检查结果与治疗开始时间的关系。
J Reprod Med. 1976 Feb;16(2):65-71.
10
Vaginal adenosis and other diethylstilbestrol-related abnormalities.阴道腺病及其他与己烯雌酚相关的异常情况。
Clin Obstet Gynecol. 1975 Sep;18(3):185-94. doi: 10.1097/00003081-197509000-00021.