四种人类癌细胞系DLD-1、HCT-15、HCT-8和HRT-18是否源自同一患者？
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?
作者信息
Vermeulen S J, Chen T R, Speleman F, Nollet F, Van Roy F M, Mareel M M
机构信息
Department of Radiotherapy and Nuclear Medicine, University Hospital Gent, Belgium.
出版信息
Cancer Genet Cytogenet. 1998 Nov;107(1):76-9. doi: 10.1016/s0165-4608(98)00081-8.
Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed alpha-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of alpha-catenin and the ensuing acquisition of invasiveness in all four cell lines.
四种具有上皮样形态型的人结肠癌细胞系HCT - 8、HRT - 18、DLD - 1和HCT - 15可重复性地形成α - 连环蛋白缺陷的圆形细胞。通过DNA指纹分析，我们发现这四种细胞系具有相同的遗传背景。我们的发现有力地表明，在所有这四种细胞系中，α - 连环蛋白的可重复性缺失以及随之而来的侵袭性获得存在遗传背景。
Zotero 插件