Transformations et Agroressources, ULR 7519, Institut Polytechnique UniLaSalle, Université d'Artois, 60000 Beauvais, France.
HCS Pharma, 59120 Loos, France.
Int J Mol Sci. 2023 Feb 10;24(4):3595. doi: 10.3390/ijms24043595.
The use of cell models is common to mimic cellular and molecular events in interaction with their environment. In the case of the gut, the existing models are of particular interest to evaluate food, toxicants, or drug effects on the mucosa. To have the most accurate model, cell diversity and the complexity of the interactions must be considered. Existing models range from single-cell cultures of absorptive cells to more complex combinations of two or more cell types. This work describes the existing solutions and the challenges that remain to be solved.
细胞模型的使用常用于模拟细胞和分子与环境相互作用的过程。在肠道的情况下，现有的模型特别有助于评估食物、毒物或药物对粘膜的影响。为了获得最准确的模型，必须考虑细胞多样性和相互作用的复杂性。现有的模型范围从吸收细胞的单细胞培养到两种或更多细胞类型的更复杂组合。本文描述了现有的解决方案和仍然需要解决的挑战。
