Ilinsky I A, Kultas-Ilinsky K, Rosina A, Haddy M
Neuroscience. 1987 Apr;21(1):207-27. doi: 10.1016/0306-4522(87)90334-4.
Quantitative and qualitative analysis of crossed vs uncrossed projections from the substantia nigra, entopeduncular nucleus and individual cerebellar nuclei to the thalamus was undertaken in nine adult cats using retrograde labeling with horseradish peroxidase and fluorescent dyes. The results indicate that about 90% of entopeduncular nucleus neurons and 50% of substantia nigra neurons give rise to ipsilateral projections to the thalamus whereas the contralateral component of these projections originates from about 10 and 7% neurons of entopeduncular nucleus and substantia nigra, respectively. Some of the fibers constituting the contralateral component are represented by branching axon collaterals of the neurons projecting ipsilaterally. In the basal ganglia thalamic projection, its minor component (contralateral) targets the ventral anterior and ventral medial nuclei the same as its major component (ipsilateral). However, some preferential distribution of the contralateral projections to the ventral medial nucleus appears to exist. In regard to the cerebellothalamic projections it was found that about 90% of neurons located in the dentate and interpositus nuclei and 50% of neurons in the fastigial nucleus project to the contralateral thalamus while 16% of dentate nucleus neurons and 40% of fastigial nucleus neurons give rise to the ipsilateral cerebellothalamic projections. A considerable number of ipsilateral cerebellothalamic fibers are represented by divergent axon collaterals of the same neurons projecting to the contralateral thalamus. The cerebellothalamic projections from all cerebellar nuclei including the fastigial nucleus are targeted primarily to the ventral lateral nucleus both contra- and ipsilaterally. The ventral medial nucleus receives bilateral input from the fastigial nucleus which originates from about one quarter of the thalamus projecting neurons in this nucleus. Of all other cerebellar nuclei only the dentate nucleus projects to the ventral medial nucleus and this projection is exclusively contralateral.
采用辣根过氧化物酶和荧光染料逆行标记法，对9只成年猫黑质、脚内核和各个小脑核团至丘脑的交叉与不交叉投射进行了定量和定性分析。结果表明，约90%的脚内核神经元和50%的黑质神经元发出丘脑同侧投射，而这些投射的对侧成分分别起源于约10%和7%的脚内核和黑质神经元。构成对侧成分的一些纤维由同侧投射神经元的分支轴突侧支代表。在基底神经节-丘脑投射中，其较小成分（对侧）与主要成分（同侧）一样，靶向腹前核和腹内侧核。然而，对侧投射在腹内侧核似乎存在一些优先分布。关于小脑-丘脑投射，发现位于齿状核和间位核的约90%的神经元以及顶核的50%的神经元投射至对侧丘脑，而16%的齿状核神经元和40%的顶核神经元发出同侧小脑-丘脑投射。相当数量的同侧小脑-丘脑纤维由投射至对侧丘脑的同一神经元的发散轴突侧支代表。包括顶核在内的所有小脑核团的小脑-丘脑投射主要双侧靶向腹外侧核。腹内侧核接受来自顶核的双侧输入，该输入起源于该核中约四分之一的丘脑投射神经元。在所有其他小脑核团中，只有齿状核投射至腹内侧核，且该投射完全是对侧的。
