Merzhanova G Kh, Dolbakyan E E, Partev A Z
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Neurosci Behav Physiol. 1998 Sep-Oct;28(5):533-8. doi: 10.1007/BF02463014.
Cats were initially trained to make operant conditioned food responses to light by an "active selection of reinforcement" method. Provision of low-quality (a mixture of meat and bread) or high-quality (meat) reinforcement depended on the animal pressing a pedal in response to switching on a light with a short (1 sec) or long (10 sec) delay. Some animals responded to long delays--group I, animals with "self control," while others responded with short delays--group II, "impulsive" animals. Implanted semimicroelectrodes were used in chronic experiments to record multineuron activity in the basolateral amygdala. Cross-correlation analysis was used to study interneuron interactions in the spike discharges of individual neurons, extracted from multineuron activity. The numbers of interneuron interactions were significantly higher in "impulsive" cats of group II in all behavioral situations than in animals with "self control," and were dominated in "impulsive" animals by the shortest connections, with latencies of 0-30 msec. The largest numbers of connections in both groups were seen on omission of the conditioned pedal-pressing movement response, i.e., when the reinforcement selection task was more difficult. These data indicate that the basolateral amygdala should be regarded as a structure determining the individual typological characteristics of the animals' behavior.
最初通过“主动选择强化”方法训练猫对光做出操作性条件反射食物反应。提供低质量（肉和面包的混合物）或高质量（肉）强化物取决于动物在短延迟（1秒）或长延迟（10秒）的灯光亮起时踩踏板的情况。一些动物对长延迟有反应——第一组，具有“自我控制”能力的动物，而其他动物对短延迟有反应——第二组，“冲动”的动物。在慢性实验中使用植入的半微电极记录基底外侧杏仁核中的多神经元活动。交叉相关分析用于研究从多神经元活动中提取的单个神经元的尖峰放电中的中间神经元相互作用。在所有行为情况下，第二组“冲动”猫中的中间神经元相互作用数量显著高于具有“自我控制”能力的动物，并且在“冲动”动物中，最短连接（潜伏期为0 - 30毫秒）占主导。两组中最大数量的连接出现在条件性踩踏板运动反应被省略时，即当强化物选择任务更困难时。这些数据表明，基底外侧杏仁核应被视为决定动物行为个体类型特征的结构。
