van Bruggen N, Busch E, Palmer J T, Williams S P, de Crespigny A J
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080, USA.
J Cereb Blood Flow Metab. 1998 Nov;18(11):1178-83. doi: 10.1097/00004647-199811000-00003.
Contrast-enhanced magnetic resonance imaging was used to produce high-resolution activation maps reflecting local changes in cerebral blood volume after a simple sensory stimulus. Activation of the forelimb region of the somatosensory cortex was performed in alpha-chloralose-anaesthetized rats with an electrical stimulus (5 V, 3 Hz) delivered through needle electrodes placed subcutaneously on the left forelimb. A gradient echo magnetic resonance imaging sequence, sensitive to changes in the relative amount of deoxyhemoglobin within the cerebral vasculature, produced a 4.05%+/-1.69% increase in signal intensity. This effect was enhanced with an injection of an intravascular iron oxide contrast agent (Combidex, Advanced Magnetics), resulting in a 9.11%+/-1.52% decrease in signal intensity.
使用对比增强磁共振成像来生成高分辨率激活图，以反映简单感觉刺激后脑血容量的局部变化。在经α-氯醛糖麻醉的大鼠中，通过置于左前肢皮下的针电极施加电刺激（5 V，3 Hz）来激活体感皮层的前肢区域。一种对脑血管内脱氧血红蛋白相对含量变化敏感的梯度回波磁共振成像序列使信号强度增加了4.05%±1.69%。注射血管内氧化铁造影剂（Combidex，Advanced Magnetics）后这种效应增强，导致信号强度降低了9.11%±1.52%。
