Culver Joseph P, Siegel Andrew M, Franceschini Maria Angela, Mandeville Joseph B, Boas David A
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.
Neuroimage. 2005 Oct 1;27(4):947-59. doi: 10.1016/j.neuroimage.2005.05.052.
With the aim of evaluating the relative performance of hemodynamic contrasts for mapping brain activity, the spatio-temporal response of oxy-, deoxy-, and total-hemoglobin concentrations were imaged with diffuse optical tomography during electrical stimulation of the rat somatosensory cortex. For both 6-s and 30-s stimulus durations, total hemoglobin images provided smaller activation areas than oxy- or deoxy-hemoglobin images. In addition, analysis of regions of interest near the sagittal sinus vein show significantly greater contrast in both oxy- and deoxy-relative to total hemoglobin, suggesting that oximetric contrasts have larger draining vein contributions compared to total hemoglobin contrasts under the given stimulus conditions. These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms.
为了评估用于绘制大脑活动的血流动力学对比的相对性能，在对大鼠体感皮层进行电刺激期间，利用扩散光学断层扫描对氧合血红蛋白、脱氧血红蛋白和总血红蛋白浓度的时空响应进行了成像。对于6秒和30秒的刺激持续时间，总血红蛋白图像提供的激活区域比氧合血红蛋白或脱氧血红蛋白图像更小。此外，对矢状窦静脉附近感兴趣区域的分析表明，相对于总血红蛋白，氧合血红蛋白和脱氧血红蛋白的对比度显著更高，这表明在给定的刺激条件下，血氧测定对比度相对于总血红蛋白对比度对引流静脉的贡献更大。这些结果表明，总血红蛋白和脑血容量作为血流动力学映射对比可能具有优势，特别是对于大振幅、持续时间更长的刺激范式。
