Busato A, Fumene Feruglio P, Parnigotto P P, Marzola P, Sbarbati A
University of Verona, Department of Computer Science.
Eur J Histochem. 2016 Nov 28;60(4):2725. doi: 10.4081/ejh.2016.2725.
In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.
体内成像技术可与经典组织化学相结合，以创建水的实际组织化学。特别是磁共振成像（MRI），一种主要在临床/临床前研究中用作诊断工具的成像技术，具有出色的解剖分辨率、无限的穿透深度和固有的软组织对比度。由于技术的发展，MRI不仅能够提供形态学信息，而且更有趣的是还能提供功能、生物物理和分子信息。在本文中，我们描述了几种先进成像技术的主要特点，如MRI显微镜、磁共振波谱、功能MRI、扩散张量成像以及使用造影剂的MRI，作为对经典组织化学的有用支持。
