Nyenhuis D L, Gorelick P B
Center for Stroke Research, Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
J Am Geriatr Soc. 1998 Nov;46(11):1437-48. doi: 10.1111/j.1532-5415.1998.tb06015.x.
The past decade has seen a renewed interest in vascular dementia. Key epidemiologic studies have examined the prevalence, incidence, course and risk factors of vascular dementia. New classification systems have been developed to improve the reliability of the diagnosis, and there have been advances in diagnostic methodology, such as neuroimaging and neuropsychological assessment. New treatments for vascular dementia are being developed to protect the brain from cerebral ischemia and to limit progression of cognitive impairment. Diagnostic criteria for vascular dementia remain to be validated by carefully designed, systematic, clinicopathologic study. Once such criteria are validated, meaningful study of subgroups of vascular dementia can be explored. Until the relationship between vascular dementia and Alzheimer's disease is better defined, the nosology for vascular dementia may be defined best as dementia associated with stroke.
在过去十年中，人们对血管性痴呆症重新产生了兴趣。关键的流行病学研究已经考察了血管性痴呆症的患病率、发病率、病程及风险因素。新的分类系统已经开发出来，以提高诊断的可靠性，并且在诊断方法上也有进展，比如神经影像学和神经心理学评估。针对血管性痴呆症的新疗法正在研发中，旨在保护大脑免受脑缺血影响，并限制认知障碍的进展。血管性痴呆症的诊断标准仍有待通过精心设计、系统的临床病理研究来验证。一旦此类标准得到验证，就可以探索对血管性痴呆症亚组进行有意义的研究。在血管性痴呆症与阿尔茨海默病之间的关系得到更好界定之前，血管性痴呆症的疾病分类学或许最好定义为与中风相关的痴呆症。
