Hänichen T, Reid H W, Wiesner H, Hermanns W
Institut für Tierpathologie der Ludwig-Maximilians-Universität München.
Tierarztl Prax Ausg G Grosstiere Nutztiere. 1998 Sep;26(5):294-300.
An outbreak of malignant catarrhal fever (MCF) in Indian gauer (Bos gaurus gaurus) and Javan banteng (Bos javanicus javanicus) occurred in the year 1964 and killed almost all animals of the groups of these species kept at the Munich zoo at that time. In the consecutive years at highly irregular intervals cases of the head-and-eye-form of MCF occurred sporadically at the zoo in European and American bison (Bison bonasus, B. bison' bison, B. bison athabascae), elk (Alces alces), red deer (Cervus elaphus), Père David's deer (Elaphurus davidianus) and again in gaur and banteng. The clinical and pathomorphological observations, including those of prophylactic and tentative treatment are reported. The subspecies of caprinae and alcelaphinae potentionally latently infected with viral agents of MCF kept at the zoo over the reported period are listed. Some details concerning housing, taking care of the animals etc. of the latently infected carriers of the family caprinae and the susceptible species of bovidae and cervidae are also given as far as they are of epidemiological interest. The results of the retrospective analysis and the results of testing paraffin-embedded tissue samples for the presence of ovine herpesvirus-2 (OHV-2)-specific DNA and alcelaphine herpesvirus-1 (AHV-1)-specific DNA from 1964 up to 1997 are discussed. The negative results for OHV-2-specific DNA suggest that MCF at Munich zoo until 1979 could have been "wildebeest-associated", also because until 1974 blue wildebeest (Connochaetes taurinus taurinus) and until 1983 white-tailed gnu (Connochaetes gnou) were kept. However, positive results for OHV-2-specific DNA in the tissues collected from 1985 onwards, strongly suggest the "sheep-associated" MCF.
1964年，印度野牛（Bos gaurus gaurus）和爪哇牛（Bos javanicus javanicus）爆发了恶性卡他热（MCF），当时慕尼黑动物园中饲养的这些物种的几乎所有动物都死亡。在随后的几年里，间隔极不规律，MCF的头眼型病例偶尔在欧洲和美洲野牛（Bison bonasus、B. bison' bison、B. bison athabascae）、麋鹿（Alces alces）、马鹿（Cervus elaphus）、大卫鹿（Elaphurus davidianus）以及印度野牛和爪哇牛中出现。报告了临床和病理形态学观察结果，包括预防性和试验性治疗的观察结果。列出了在报告期间动物园饲养的可能潜在感染MCF病毒的山羊亚科和牛羚亚科的亚种。还给出了一些关于山羊亚科潜在感染携带者以及牛科和鹿科易感物种的饲养、照料动物等方面的细节，只要这些细节具有流行病学意义。讨论了回顾性分析的结果以及1964年至1997年对石蜡包埋组织样本检测绵羊疱疹病毒2（OHV - 2）特异性DNA和牛羚疱疹病毒1（AHV - 1）特异性DNA的结果。OHV - 2特异性DNA的阴性结果表明，直到1979年慕尼黑动物园的MCF可能与“牛羚相关”，这也是因为直到1974年蓝牛羚（Connochaetes taurinus taurinus）以及直到1983年白尾牛羚（Connochaetes gnou）都在饲养。然而，1985年以后收集的组织中OHV - 2特异性DNA的阳性结果强烈表明是“绵羊相关”的MCF。
