三乙烯四胺二盐酸盐对铜绿假单胞菌抗生素敏感性的影响。
Effect of triethylenetetramine dihydrochloride on the antibiotic susceptibility of Pseudomonas aeruginosa.
作者信息
Light B, Riggs H G
出版信息
Antimicrob Agents Chemother. 1978 Jun;13(6):979-84. doi: 10.1128/AAC.13.6.979.
Abstract
A chelating agent, triethylenetetramine dihydrochloride, interacted synergistically in vitro with both gentamicin and carbenicillin against a clinical isolate of Pseudomonas aeruginosa designated Ps 15. The minimal inhibitory concentrations of carbenicillin and gentamicin for Ps 15 in a 50% serum-Trypticase soy broth were 250 and 72.9 mug/ml, respectively. However, addition of triethylenetetramine dihydrochloride to the 50% serum-Trypticase soy broth reduced the minimal inhibitory concentration of both antibiotics approximately 10-fold. A comparison of the growth of Ps 15 in 50% serum-Trypticase soy broth containing either of the antibiotics showed that a rapid decrease in the percentage of survivors only occurred when the chelating agent was present.
摘要
一种螯合剂，即二盐酸三亚乙基四胺，在体外与庆大霉素和羧苄青霉素协同作用，对抗一株名为Ps 15的铜绿假单胞菌临床分离株。在50%血清-胰蛋白胨大豆肉汤中，羧苄青霉素和庆大霉素对Ps 15的最低抑菌浓度分别为250μg/ml和72.9μg/ml。然而，向50%血清-胰蛋白胨大豆肉汤中添加二盐酸三亚乙基四胺可使两种抗生素的最低抑菌浓度降低约10倍。对Ps 15在含有任何一种抗生素的50%血清-胰蛋白胨大豆肉汤中的生长情况进行比较，结果表明，只有当螯合剂存在时，存活菌百分比才会迅速下降。
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本文引用的文献
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Characterization of a protein-lipopolysaccharide complex released from cell walls of Pseudomonas aeruginosa by ethylenediaminetetraacetic acid.通过乙二胺四乙酸从铜绿假单胞菌细胞壁释放的蛋白质-脂多糖复合物的特性分析。
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In vitro reversal of antibiotic resistance by ethylenediamine tetraacetic acid.乙二胺四乙酸对体外抗生素耐药性的逆转作用。
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Action of ethylenediaminetetraacetic acid, tris(hydroxymethyl)-aminomethane, and lysozyme on cell walls of Pseudomonas aeruginosa.乙二胺四乙酸、三（羟甲基）氨基甲烷和溶菌酶对铜绿假单胞菌细胞壁的作用。
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