缺血性心脏病的遗传学
Genetics of ischaemic heart disease.
作者信息
Epstein F H
出版信息
Postgrad Med J. 1976 Aug;52(610):477-80. doi: 10.1136/pgmj.52.610.477.
Abstract
Coronary heart disease, especially when it affects younger individuals, tends to cluster in families. Known risk factors occur in 50-75% of patients with myocardial infarction. Yet commonly occurring risk factors are not strongly inherited, and the familial aggregation of coronary heart diseas may not be attributable to familial resemblance in serum cholesterol and blood pressure levels. Alternatively, such aggregation may be due to unknown familial risk factors. Nevertheless, screening of relatives of individuals with evident risk factors is of importance, and environmental manipulation is likely to be of value in prevention of coronary heart disease.
摘要
冠心病，尤其是在影响较年轻个体时，往往在家族中聚集。已知的危险因素出现在50%-75%的心肌梗死患者中。然而，常见的危险因素并没有很强的遗传性，冠心病的家族聚集现象可能并非归因于血清胆固醇和血压水平上的家族相似性。或者，这种聚集可能是由于未知的家族危险因素。尽管如此，对有明显危险因素的个体的亲属进行筛查很重要，并且环境干预在预防冠心病方面可能具有价值。
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本文引用的文献
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Risk factors in coronary heart disease--environmental and hereditary influences.冠心病的危险因素——环境与遗传影响
Isr J Med Sci. 1967 Jul-Aug;3(4):594-607.
2
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Acta Med Scand. 1966 Sep;180(3):307-15. doi: 10.1111/j.0954-6820.1966.tb02840.x.
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Familial factors in premature coronary heart disease--a preliminary report from the Tecumseh Community Health Study.
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Coronary artery disease in 116 kindred with familial type II hyperlipoproteinemia.
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Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.冠心病中的高脂血症。II. 176个家族血脂水平的遗传分析及一种新的遗传性疾病——混合型高脂血症的描述
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Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.冠心病中的高脂血症。I. 500例心肌梗死幸存者的血脂水平。
J Clin Invest. 1973 Jul;52(7):1533-43. doi: 10.1172/JCI107331.
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