Carson J H, Kwon S, Barbarese E
Department of Biochemistry, University of Connecticut Health Center, Farmington 06030, USA.
Curr Opin Neurobiol. 1998 Oct;8(5):607-12. doi: 10.1016/s0959-4388(98)80088-3.
In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes that binds specifically to the RNA transport sequence; and microtubules and kinesin have been identified as cytoskeletal elements required for RNA transport in oligodendrocytes.
在过去的一年里，已鉴定出了髓鞘形成细胞中RNA转运途径的几个关键分子成分：髓鞘碱性蛋白mRNA中已对RNA转运和定位的不同顺式作用元件进行了表征；异质性核糖核蛋白A2已被鉴定为少突胶质细胞中的一种反式作用因子，它能特异性结合RNA转运序列；微管和驱动蛋白已被鉴定为少突胶质细胞中RNA转运所需的细胞骨架成分。
