Grisaru N, Chudakov B, Yaroslavsky Y, Belmaker R H
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Am J Psychiatry. 1998 Nov;155(11):1608-10. doi: 10.1176/ajp.155.11.1608.
Left prefrontal transcranial magnetic stimulation has been reported to have ECT-like effects in depression; therefore, the authors planned a study of transcranial magnetic stimulation in mania.
Sixteen patients completed a 14-day double-blind, controlled trial of right versus left prefrontal transcranial magnetic stimulation at 20 Hz (2-second duration per train, 20 trains/day for 10 treatment days). Mania was evaluated with the Mania Scale, the Brief Psychiatric Rating Scale, and the Clinical Global Impression.
Significantly more improvement was observed in patients treated with right than with left prefrontal transcranial magnetic stimulation.
The therapeutic effect of transcranial magnetic stimulation in mania may show laterality opposite to its effect in depression.
据报道，左侧前额叶经颅磁刺激在抑郁症中具有类似电休克治疗的效果；因此，作者计划开展一项关于经颅磁刺激治疗躁狂症的研究。
16名患者完成了一项为期14天的双盲对照试验，比较右侧与左侧前额叶20赫兹经颅磁刺激（每串持续2秒，每天20串，共治疗10天）的效果。使用躁狂量表、简明精神病评定量表和临床总体印象量表对躁狂症进行评估。
接受右侧前额叶经颅磁刺激治疗的患者比接受左侧治疗的患者有更显著的改善。
经颅磁刺激治疗躁狂症的疗效可能与其治疗抑郁症的效果存在相反的偏侧性。
