George M S, Wassermann E M, Kimbrell T A, Little J T, Williams W E, Danielson A L, Greenberg B D, Hallett M, Post R M
Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA.
Am J Psychiatry. 1997 Dec;154(12):1752-6. doi: 10.1176/ajp.154.12.1752.
Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design.
Twelve depressed adults received in random order 2 weeks of active treatment (repetitive transcranial magnetic stimulation, 20 Hz at 80% motor threshold) and 2 weeks of sham treatment.
Changes from the relevant phase baseline in scores on the 21-item Hamilton depression scale showed that repetitive transcranial magnetic stimulation significantly improved mood over sham treatment. During the active-treatment phase, Hamilton depression scale scores decreased 5 points, while during sham treatment the scores increased or worsened by 3 points. No adverse effects were noted.
These placebo-controlled results suggest that daily left prefrontal repetitive transcranial magnetic stimulation has antidepressant activity when administered at these parameters. Further controlled studies are indicated to explore optimal stimulation characteristics and location, potential clinical applications, and possible mechanisms of action.
初步研究表明，每日对左侧前额叶进行重复经颅磁刺激可能具有抗抑郁活性。作者试图通过双盲交叉设计来证实这一发现。
12名成年抑郁症患者按随机顺序接受2周的积极治疗（重复经颅磁刺激，频率20赫兹，强度为运动阈值的80%）和2周的假治疗。
21项汉密尔顿抑郁量表得分与相应阶段基线相比的变化表明，重复经颅磁刺激在改善情绪方面显著优于假治疗。在积极治疗阶段，汉密尔顿抑郁量表得分下降了5分，而在假治疗期间得分增加或恶化了3分。未观察到不良反应。
这些安慰剂对照结果表明，按这些参数进行每日左侧前额叶重复经颅磁刺激具有抗抑郁活性。需要进一步进行对照研究，以探索最佳刺激特征和部位、潜在临床应用及可能的作用机制。
