Kieć-Kononowicz K, Szymańska E, Motyl M, Holzer W, Białecka A, Kasprowicz A
Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Pharmazie. 1998 Oct;53(10):680-4.
The synthesis of new chloro-benzylidene substituted derivatives of hydantoin and their antimicrobial activity is reported. The structure-activity relationships showed that the antibacterial effect of investigated compounds depends on the distance of the phenyl ring from the amine residue and the kind of substitutes on the phenyl ring. In the investigated group of derivatives, 5-(2-chlorobenzylidene)-2-(4-fluorobenzylamine)-imidazoline-4-one and 5-(2-chlorobenzylidene)-2-(2-phenylethylamine)-imidazoline-4-one showed the best antibacterial activity against Moraxella catarrhalis.
报道了新型氯代亚苄基取代的乙内酰脲衍生物的合成及其抗菌活性。构效关系表明，所研究化合物的抗菌效果取决于苯环与胺残基的距离以及苯环上取代基的种类。在所研究的衍生物组中，5-(2-氯亚苄基)-2-(4-氟苄胺)-咪唑啉-4-酮和5-(2-氯亚苄基)-2-(2-苯乙胺)-咪唑啉-4-酮对卡他莫拉菌显示出最佳抗菌活性。
