2-硫尿嘧啶的S-取代衍生物的合成及其抗菌性能
Synthesis and antimicrobial properties of S-substituted derivatives of 2-thiouracil.
作者信息
Wyrzykiewicz E, Bartkowiak G, Nowakowska Z, Kedzia B
机构信息
Instytut Roślin i Przetworów Zielarskich, Poznań, Polska.
出版信息
Farmaco. 1993 Jul;48(7):979-88.
PMID:8397680
Abstract
The synthesis of 24 new 2-alkylthio and 2-(E)-N-thioalkyl-4-azachalkonyl substituted derivatives of uracil and their antimicrobial activity are reported. In particularly compounds 6o and 6p showed a good antibacterial activity against Staphylococcus aureus and Streptococcus faecalis.
摘要
报道了24种新的2-烷硫基和2-(E)-N-硫代烷基-4-氮杂查尔酮基取代的尿嘧啶衍生物的合成及其抗菌活性。特别是化合物6o和6p对金黄色葡萄球菌和粪肠球菌表现出良好的抗菌活性。
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