活血化瘀法治疗真性红细胞增多症的临床观察与治疗机制
[Activating blood circulation and removing stasis in treating polycythemia vera: clinical observation and therapeutical mechanism].
作者信息
Tang X P, Tian Z, Zhang D
机构信息
Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin.
出版信息
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Jan;17(1):20-2.
OBJECTIVE
To assess the efficacy of "method of activating blood circulation and removing stasis (ABCRS)" in treating polycythemia vera.
METHODS
28 cases of polycythemia vera were treated with ABCRS and observed with bone marrow colonies.
RESULTS
15 casses were responsibe, of them 4 cases reached clinical remission, 11 cases were improved. Both bone marrow colonies of colony forming unit-erythroid dependent of erythropoietin (EPO + CFU-E) and colonies of CFU-E independent of EPO. (EPO-CFU-E) from these cases decreased significantly, especially the latter. ABCRS mainly suppressed the proliferation and differentiation of EPO-CFU-E. In addition, bone marrow colonies of colony formng unit-fibroblastoids (CFU-F) from these cases also changed obviously.
CONCLUSION
ABCRS is effective in treating polycythemia vera.
目的
评估“活血化瘀法”治疗真性红细胞增多症的疗效。
方法
采用活血化瘀法治疗28例真性红细胞增多症患者，并进行骨髓集落观察。
结果
15例有效，其中4例临床缓解，11例好转。这些病例中促红细胞生成素依赖的红系集落形成单位（EPO+CFU-E）和非促红细胞生成素依赖的CFU-E（EPO-CFU-E）骨髓集落均显著减少，尤其是后者。活血化瘀法主要抑制EPO-CFU-E的增殖和分化。此外，这些病例中的成纤维细胞样集落形成单位（CFU-F）骨髓集落也有明显变化。
结论
活血化瘀法治疗真性红细胞增多症有效。
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