Dong X, Shan G X, Zhang H D
Institute of Radiation Medicine, Shanghai Medical University.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Jun;17(6):334-5.
To evaluate the therapeutical mechanism of Bushen Shengxue Paste (BSSXP) on anemia.
Chronic renal failure induced anemia patients were treated with BSSXP, clinical manifestation, anemia and renal function as indicators were observed in patients. The erythropoietin (EPO) and inhibition of colony-forming unit-erythrocyte (CFU-E) in patients' serum were determined by CFU-E in vitro.
The patients' symptoms, renal function and anemia were improved after administration with BSSXP 1-2 course. EPO in serum was slightly increased. The inhibition of CFU-E in patient's serum was significantly decreased.
BSSXP could improve the anemia degree, its mechanism might be through clearing the inhibitor of CFU-E in serum.
评价补肾生血膏（BSSXP）治疗贫血的作用机制。
采用补肾生血膏治疗慢性肾衰竭所致贫血患者，观察患者的临床表现、贫血及肾功能指标。采用体外集落形成单位-红细胞（CFU-E）法测定患者血清促红细胞生成素（EPO）及CFU-E抑制率。
补肾生血膏治疗1-2个疗程后患者症状、肾功能及贫血情况均有改善。血清EPO略有升高。患者血清CFU-E抑制率明显降低。
补肾生血膏可改善贫血程度，其机制可能是通过清除血清中CFU-E抑制剂实现的。
