Yi C Q, Sun J N, Zhang J J
Central Research Laboratory of Beijing University of Traditional Chinese Medicine.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Jan;17(1):42-4.
To observe the Sijunzi Decoction in rectifying the digestive disorder.
Sijunzi decoction (SJZD) was chosen to treat digestive dysfunction in mice. The model was induced by Xiaochengqi decoction and semi-starvation. The effects on the absorptive function of the small intestine, body weight, autonomous activity levels, oxidative phosphorylation of hepatic mitochondrion, respiratory control rate (RCR) and cells energy charge were observed in vivo.
The group given Xiaochengqi decoction had lower absorption, decreased body weight, and lower autonomous activity levels, and their hepatic mitochondrion RCR and cell energy charge were also lower than those of the control group. The figures for the group given SJZD all showed improvement, especially the group given the larger dose of SJZD.
SJZD could correct Deficiency of the Spleen and Stomach which to some extent is caused by digestive dysfunction. So it is considered that the Spleen's function of transportation and transformation includes two meanings: external transportation and transformation--the digestive and absorptive function of the small intestine, and internal transportation and transformation--the liver's conversion of nutrients and generate energy (ATP).
观察四君子汤对消化功能紊乱的调理作用。
选用四君子汤治疗小鼠消化功能障碍。采用小承气汤结合半饥饿法诱导小鼠建立模型。观察其对小肠吸收功能、体重、自主活动水平、肝线粒体氧化磷酸化、呼吸控制率（RCR）及细胞能量电荷的影响。
给予小承气汤的小鼠吸收功能降低，体重减轻，自主活动水平下降，其肝线粒体RCR及细胞能量电荷也低于对照组。给予四君子汤的各剂量组各项指标均有改善，尤其大剂量四君子汤组。
四君子汤可纠正脾胃虚弱，而脾胃虚弱在一定程度上是由消化功能障碍引起的。由此认为脾的运化功能包括两方面含义：外在运化——小肠的消化吸收功能，内在运化——肝脏对营养物质的转化及产生能量（ATP）。
