Ren P, Huang X, Jiang Y P
Tangdu Hospital, Fourth Military Medical University, Xi'an.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Jan;17(1):45-7.
To explore relationship between the essence of Spleen Deficiency Syndrome (SDS) and pharmacokinetic characteristics (PK).
The level of motilin in serum and intestine, and PK of tetramethylpyrazine phosphate (TMPP) in rat model of SDS were observed simultaneously and treated with Sijunzi decoction (SJZD) for confirmation.
The atrioventricular model of TMPP in SDS, normal and SJZD treated rats all belonged to the open double ventricular type; there were insignificant differences between normal and SJZD treated rats in motilin level and PK of TMPP, but the differences of these parameters between normal and SDS model rats were significantly (P < 0.01). The SDS state could markedly affect the absorption, distribution, metabolism and elimination of TMPP in rat; SJZD could normalize the abnormal PK of TMPP in SDS model rats.
A supplementary scientific evidence for the hypothesis of "Pharmacokinetics of Syndrome Differentiation" is provided.
探讨脾虚证本质与药代动力学特征之间的关系。
同步观察脾虚证大鼠模型血清及肠道中胃动素水平，以及磷酸川芎嗪（TMPP）的药代动力学，并用四君子汤（SJZD）治疗进行验证。
脾虚证、正常及四君子汤治疗大鼠中磷酸川芎嗪的房室模型均属开放双室型；正常及四君子汤治疗大鼠的胃动素水平和磷酸川芎嗪药代动力学无显著差异，但正常与脾虚证模型大鼠之间这些参数的差异显著（P<0.01）。脾虚状态可显著影响大鼠体内磷酸川芎嗪的吸收、分布、代谢和排泄；四君子汤可使脾虚证模型大鼠磷酸川芎嗪异常的药代动力学正常化。
为“辨证药动学”假说提供了补充性科学依据。
