[Effect of sijunzi decoction on motilin and pharmacokinetic characteristics of tetramethylpyrazine in rat model of spleen deficiency syndrome].

OBJECTIVE

To explore relationship between the essence of Spleen Deficiency Syndrome (SDS) and pharmacokinetic characteristics (PK).

METHODS

The level of motilin in serum and intestine, and PK of tetramethylpyrazine phosphate (TMPP) in rat model of SDS were observed simultaneously and treated with Sijunzi decoction (SJZD) for confirmation.

RESULTS

The atrioventricular model of TMPP in SDS, normal and SJZD treated rats all belonged to the open double ventricular type; there were insignificant differences between normal and SJZD treated rats in motilin level and PK of TMPP, but the differences of these parameters between normal and SDS model rats were significantly (P < 0.01). The SDS state could markedly affect the absorption, distribution, metabolism and elimination of TMPP in rat; SJZD could normalize the abnormal PK of TMPP in SDS model rats.

CONCLUSIONS

A supplementary scientific evidence for the hypothesis of "Pharmacokinetics of Syndrome Differentiation" is provided.