尼莫地平对兔感染性脑水肿的影响。

Effect of nimodipine on infectious brain edema in rabbits.

作者信息

Wen F Q, Zhang B L, Yu P L, Tao Y G

机构信息

Department of Pediatrics, Hu-nan Medical University, Changsha, China.

出版信息

Zhongguo Yao Li Xue Bao. 1996 May;17(3):212-4.

PMID:9812737

Abstract

AIM

To study the effect of nimodipine (Nim) on infectious brain edema (BE).

METHODS

An infectious BE model was induced by injection of Bordetella pertussis suspension (BPS) into right internal carotid artery in rabbits. Eighteen rabbits were randomly divided into 3 groups (n = 6). Group BE: BPS (0.6 mL.kg-1) was given; group NS: normal saline was given as control; group Nim: 10 min after injection of BPS, Nim, 10 micrograms.kg-1, was injected i.v. as a bolus followed by continuous infusion of 0.75 microgram.kg-1.min-1. All the rabbits were kept under observation for 4 h. Evans blue staining was assessed; water, calcium, calmodulin (Cal), and sodium contents were determined in the right brain.

RESULTS

Nim vs BE: water 82.2 +/- 1.0% vs 84.4 +/- 1.2 (P < 0.01); calcium 10.5 +/- 1.3 mmol.kg-1 dry tissue vs 17.5 +/- 1.4 (P < 0.01); Cal 15.9 +/- 1.8 mumol.kg-1 wet tissue vs 24.0 +/- 3.0 (P < 0.01); sodium 173 +/- 7 mmol.kg-1 dry tissue vs 275 +/- 38 (P < 0.05). No significant difference for Evans blue staining between the two groups.

CONCLUSION

Nim had beneficial effect on the infectious BE.

摘要

目的

研究尼莫地平（Nim）对感染性脑水肿（BE）的影响。

方法

通过向家兔右颈内动脉注射百日咳博德特氏菌悬液（BPS）诱导建立感染性BE模型。18只家兔随机分为3组（n = 6）。BE组：给予BPS（0.6 mL·kg-1）；NS组：给予生理盐水作为对照；Nim组：注射BPS 10分钟后，静脉推注10微克·kg-1的Nim，随后以0.75微克·kg-1·min-1的速度持续输注。所有家兔观察4小时。评估伊文思蓝染色；测定右侧脑组织中的水、钙、钙调蛋白（Cal）和钠含量。

结果

Nim组与BE组比较：水含量82.2±1.0%对84.4±1.2（P < 0.01）；钙含量10.5±1.3 mmol·kg-1干组织对17.5±1.4（P < 0.01）；Cal含量15.9±1.8 μmol·kg-1湿组织对24.0±3.0（P < 0.01）；钠含量173±7 mmol·kg-1干组织对275±38（P < 0.05）。两组伊文思蓝染色无显著差异。