Yu G D, Yin Q Z, Hu Y M, Yin Z W, Gu Z L, Qian Z N, Qian Z M
Laboratory of Neurobiology, Suzhou Medical College, China.
Zhongguo Yao Li Xue Bao. 1996 May;17(3):271-4.
The nervous mechanism of the immune potentiating effect of Coriolus versicolor polysaccharides peptides (PSP) was studied in Wistar rats.
The unit discharge of the mediobasal hypothalamus (MBH) neurons was recorded extracellularly and the lymphocyte proliferation was measured.
PSP 1 g.kg-1 ig for 5 d increased the T-lymphocytes and promoted T-lymphocyte proliferation in spleen and peripheral blood. This promoting effect of PSP was blocked by MBH lesion. PSP increased the discharge frequency of MBH neurons, but no increase in discharge frequency was observed after treatment of PSP plus immune inhibitor, cyclosporin A.
MBH is involved in the immune-potentiating effect of PSP.
在Wistar大鼠中研究云芝多糖肽（PSP）免疫增强作用的神经机制。
细胞外记录下丘脑内侧基底部（MBH）神经元的单位放电，并检测淋巴细胞增殖情况。
PSP 1 g·kg-1灌胃5天可增加T淋巴细胞数量，并促进脾脏和外周血中T淋巴细胞的增殖。MBH损伤可阻断PSP的这种促进作用。PSP可增加MBH神经元的放电频率，但在PSP与免疫抑制剂环孢素A联合处理后，未观察到放电频率增加。
MBH参与了PSP的免疫增强作用。
