Qian Z M, Xu M F, Tang P L
Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Am J Chin Med. 1997;25(1):27-35. doi: 10.1142/S0192415X97000068.
Polysaccharide peptide (PSP) is a protein-bound polysaccharide extracted from an edible mushroom, Coriolus versicolor. Effects of PSP (2g/kg/day) on cyclophosphamide (CPA, 40 mg/kg/2 days)-induced immunosuppression were investigated by determining lymphocyte proliferation, Natural killer (NK) cell formation, IgG and IL-2 concentration, WBC count and the weight of organs after rats were treated with or without CPA in the presence or absence of PSP. The results demonstrated that PSP possessed immunopotentiating effect, being effective in restoring CPA-induced immunosuppression such as depressed lymphocyte proliferation, Natural Killer cell function, production on white blood cell and the growth of spleen and thymus in rats as well as in increasing both IgG and IL-2 production on which CPA did not have significant effects under the conditions of our experiments. PSP can partly restore CPA-induced immunosuppression. Based on our findings and the data accumulated so far, it was suggested that PSP should be considered as an useful adjuvant especially combined with CPA or other chemotherapy in clinical treatment of cancer patients. The mechanism by which PSP restores the immunosuppression induced by CPA is unclear.
多糖肽（PSP）是从食用蘑菇云芝中提取的一种蛋白结合多糖。通过在大鼠接受或未接受环磷酰胺（CPA，40mg/kg/每2天）处理且存在或不存在PSP的情况下，测定淋巴细胞增殖、自然杀伤（NK）细胞形成、IgG和IL-2浓度、白细胞计数以及器官重量，研究了PSP（2g/kg/天）对CPA诱导的免疫抑制的影响。结果表明，PSP具有免疫增强作用，可有效恢复CPA诱导的免疫抑制，如大鼠淋巴细胞增殖受抑、自然杀伤细胞功能降低、白细胞生成减少以及脾脏和胸腺生长受抑制，同时还能增加IgG和IL-2的产生，而在我们的实验条件下CPA对这些方面没有显著影响。PSP可部分恢复CPA诱导的免疫抑制。基于我们的研究结果和目前积累的数据，建议在癌症患者的临床治疗中，PSP应被视为一种有用的佐剂，尤其是与CPA或其他化疗联合使用时。PSP恢复CPA诱导的免疫抑制的机制尚不清楚。
