Gong S, Zhang H Q, Yin W P, Yin Q Z, Zhang Y, Gu Z L, Qian Z M, Tang P L
Laboratory of Neurobiology, Suzhou Medical College, China.
Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):67-70.
To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).
The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.
PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.
The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.
研究白细胞介素-2（IL-2）和下丘脑内侧基底部（MBH）在云芝多糖肽（PSP）产生镇痛作用中的作用。
通过脑室内或腹腔内注射IL-2抗血清，并用电解损伤法损毁MBH。
大鼠连续6天每天灌胃给予PSP 1 g·kg-1，可提高大鼠尾部刺激发声试验中的痛阈。这种由PSP产生的镇痛作用可被脑室内注射IL-2抗血清阻断，但腹腔内注射则不能，且在MBH电解损伤后消失。
PSP产生的镇痛作用是由PSP激活的IL-2介导的，IL-2与MBH中的IL-2受体相互作用。
