[Inhibitory effects of L-ENK on the proliferation of cultured smooth muscle cells of rats].

Using method of MTT and 3H-TdR incorporation, the effect of L-ENK on proliferation and DNA synthesis of the cultured thoracic aortic vascular smooth muscle cells (VSMCs) of SD rats was investigated. The results indicated that L-ENK (10(-5)-10(-4) mol/L) could markedly inhibit proliferation and DNA synthesis of VSMCs, while NAL (10(-8)-10(-5) mol/L) had no such effect, but could antagonize the inhibitory action of L-ENK on the proliferation of VSMCs.