Cobb J, Handel M A
Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996-0840, USA.
Semin Cell Dev Biol. 1998 Aug;9(4):445-50. doi: 10.1006/scdb.1998.0202.
This review focuses on recent developments in our understanding of meiotic chromosome behavior in mammalian spermatogenesis, with a special emphasis on prophase I events in the best characterized organism, the laboratory mouse. The dynamics of chromosome movement prior to pairing and synapsis of chromosomes are complex and implicate function for both centromeres and telomeres in getting homologous chromosomes together in intimate synapsis. Likely candidates for mediating pairing and recombination include a host of proteins implicated in DNA repair and recombination, which have been shown to localize to the synaptonemal complex during meiotic prophase I. Precocious induction of meiotic metaphase in cultured pachytene spermatocytes has led to new information about requirements for MPF and topoisomerase II activity during the transition from meiotic prophase to metaphase. Together, the studies reviewed here increase our understanding of how chromosomes get together with their homologous partners and how these partners subsequently come apart.
本综述聚焦于我们对哺乳动物精子发生过程中减数分裂染色体行为的最新认识进展，特别强调在特征最明确的生物体——实验室小鼠中前期I的事件。在染色体配对和联会之前，染色体运动的动态过程很复杂，着丝粒和端粒在使同源染色体紧密联会在一起的过程中都发挥了作用。可能介导配对和重组的候选物质包括许多与DNA修复和重组相关的蛋白质，这些蛋白质在减数分裂前期I已被证明定位于联会复合体。在培养的粗线期精母细胞中过早诱导减数分裂中期，已产生了关于从减数分裂前期到中期转变过程中对MPF和拓扑异构酶II活性需求的新信息。总之，这里综述的研究增进了我们对染色体如何与它们的同源配对物聚集在一起以及这些配对物随后如何分开的理解。
