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Regulation of expression of surfactant protein-A.

作者信息

Mendelson C R, Gao E, Li J, Young P P, Michael L F, Alcorn J L

机构信息

Departments of Biochemistry and Obstetrics-Gynecology, The Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center at Dallas, TX 75235-9038, USA.

出版信息

Biochim Biophys Acta. 1998 Nov 19;1408(2-3):132-49. doi: 10.1016/s0925-4439(98)00063-5.

DOI:10.1016/s0925-4439(98)00063-5
PMID:9813283
Abstract
摘要

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Decreased 11β-hydroxysteroid dehydrogenase 1 in lungs of steroid receptor coactivator (Src)-1/-2 double-deficient fetal mice is caused by impaired glucocorticoid and cytokine signaling.Src-1/-2 双缺失胎儿肺部中 11β-羟类固醇脱氢酶 1 的减少是由糖皮质激素和细胞因子信号受损引起的。
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表面活性蛋白 A、B、C 和 D 在婴儿唇腺和黏膜中的免疫定位。
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Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.人类表面活性剂相关蛋白 SP-A1 和 SP-A2 的遗传复杂性。
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TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity.甲状腺转录因子-1反应元件对人表面活性物质蛋白-A2启动子活性的时空调节至关重要,且是激素调节所必需的。
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Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter.糖皮质激素/糖皮质激素受体对肺II型细胞表面活性蛋白A(SP-A)基因表达的抑制作用是由SP-A启动子处组蛋白修饰的抑制性变化介导的。
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