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J Innate Immun. 2017;9(1):3-11. doi: 10.1159/000451026. Epub 2016 Oct 29.
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Labial Salivary Glands in Infants: Histochemical Analysis of Cytoskeletal and Antimicrobial Proteins.婴儿唇唾液腺：细胞骨架蛋白和抗菌蛋白的组织化学分析
J Histochem Cytochem. 2016 Aug;64(8):502-10. doi: 10.1369/0022155416656940.
3
Expression and Localization of Lung Surfactant Proteins in Human Testis.肺表面活性物质蛋白在人睾丸中的表达与定位
PLoS One. 2015 Nov 24;10(11):e0143058. doi: 10.1371/journal.pone.0143058. eCollection 2015.
4
Palate Lung Nasal Clone (PLUNC), a Novel Protein of the Tear Film: Three-Dimensional Structure, Immune Activation, and Involvement in Dry Eye Disease (DED).腭肺鼻克隆蛋白（PLUNC），一种泪膜中的新型蛋白质：三维结构、免疫激活及与干眼病（DED）的关系
Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7312-23. doi: 10.1167/iovs.15-17560.
5
Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli.表面活性蛋白A和D在尿路致病性大肠杆菌引起的尿路感染中的固有免疫。
Innate Immun. 2016 Jan;22(1):9-20. doi: 10.1177/1753425915609973. Epub 2015 Oct 28.
6
Surfactant proteins A and D are related to severity of the disease, pathogenic bacteria and comorbidity in patients with chronic rhinosinusitis with and without nasal polyps.表面活性蛋白A和D与伴或不伴鼻息肉的慢性鼻-鼻窦炎患者的疾病严重程度、病原菌及合并症相关。
Clin Otolaryngol. 2016 Jun;41(3):249-58. doi: 10.1111/coa.12508. Epub 2016 Feb 7.
7
Surfactant proteins A, B, C and D in the human nasal airway: associated with mucosal glands and ciliated epithelium but absent in fluid-phase secretions and mucus.人鼻气道中的表面活性蛋白A、B、C和D：与黏膜腺和纤毛上皮相关，但在液相分泌物和黏液中不存在。
ORL J Otorhinolaryngol Relat Spec. 2014;76(5):288-301. doi: 10.1159/000369143. Epub 2014 Dec 10.
8
The distribution of human surfactant proteins within the oral cavity and their role during infectious diseases of the gingiva.人表面活性物质蛋白在口腔内的分布及其在牙龈感染性疾病中的作用。
Ann Anat. 2015 May;199:92-7. doi: 10.1016/j.aanat.2014.05.040. Epub 2014 Jun 23.
9
SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation.SFTA3，一种肺部的新型蛋白：三维结构、特性和免疫激活。
Eur Respir J. 2014 Aug;44(2):447-56. doi: 10.1183/09031936.00179813. Epub 2014 Apr 17.
10
The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS.在人脑组织中检测表面活性蛋白 A、B、C 和 D，及其在脑梗死、自身免疫性疾病和中枢神经系统感染中的调控作用。
PLoS One. 2013 Sep 30;8(9):e74412. doi: 10.1371/journal.pone.0074412. eCollection 2013.

表面活性蛋白 A、B、C 和 D 在婴儿唇腺和黏膜中的免疫定位。

Immunolocalization of Surfactant Proteins SP-A, SP-B, SP-C, and SP-D in Infantile Labial Glands and Mucosa.

机构信息

Department of Oral and Maxillofacial Surgery, Technical University of Munich, Munich, Germany.

Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany.

出版信息

J Histochem Cytochem. 2018 Jul;66(7):531-538. doi: 10.1369/0022155418766063. Epub 2018 Mar 30.

DOI:10.1369/0022155418766063
PMID:29601229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6055263/
Abstract

Surfactant proteins in different glandular structures of the oral cavity display antimicrobial activity for protection of invading microorganisms. Moreover, they are involved in lowering liquid tension in fluids and facilitate secretion flows. Numerous investigations for studying the occurrence of surfactant proteins in glandular tissues were performed using different methods. In the oral cavity, minor salivary glands secrete saliva continuously for the maintenance of a healthy oral environment. For the first time, we could show that infantile labial glands show expression of the surfactant proteins (SP) SP-A, SP-B, SP-C, and SP-D in acinar cells and the duct system in different intensities. The stratified squamous epithelium of the oral mucosa revealed positive staining for SPs in various cell layers.

摘要

口腔不同腺体结构中的表面活性剂蛋白具有抗微生物活性，可保护入侵的微生物。此外，它们还参与降低液体的表面张力并促进分泌液流动。为了研究表面活性剂蛋白在腺体组织中的存在，人们使用了不同的方法进行了大量的研究。在口腔中，小唾液腺持续分泌唾液以维持健康的口腔环境。我们首次发现，婴儿唇腺的腺泡细胞和导管系统中均有不同强度的表面活性剂蛋白（SP）SP-A、SP-B、SP-C 和 SP-D 的表达。口腔黏膜的复层鳞状上皮在不同细胞层中均对 SP 呈阳性染色。