Lee G P, Bechara A, Adolphs R, Arena J, Meador K J, Loring D W, Smith J R
Section of Neurosurgery, Medical College of Georgia, Augusta 30912-4010, USA.
J Neuropsychiatry Clin Neurosci. 1998 Fall;10(4):413-20. doi: 10.1176/jnp.10.4.413.
The amygdala is thought to be an important neural structure underlying the "fight-or-flight" response, but information on its role in humans is scarce. The clinical and psychophysiological effects of amygdalar destruction were studied in 2 patients who underwent bilateral amygdalotomy for intractable aggression. After surgery, both patients showed a reduction in autonomic arousal levels to stressful stimuli and in the number of aggressive outbursts, although both patients continued to have difficulty controlling aggression. The "taming effect" reported after bilateral amygdalar destruction may be due to the amygdala's inadequate processing of perceived threat stimuli that would normally produce a fight-or-flight response.
杏仁核被认为是“战斗或逃跑”反应背后的重要神经结构，但关于其在人类中的作用的信息却很少。对2名因顽固性攻击行为接受双侧杏仁核切开术的患者进行了杏仁核破坏的临床和心理生理影响研究。术后，两名患者对压力刺激的自主唤醒水平和攻击爆发次数均有所减少，尽管两名患者在控制攻击行为方面仍有困难。双侧杏仁核破坏后报告的“驯服效应”可能是由于杏仁核对通常会产生战斗或逃跑反应的感知威胁刺激处理不足所致。
