Dobrotvorskiĭ A K, Moshkin M P, Chechulin A I, Panov V V, Mak V V
Parazitologiia. 1998 Jul-Aug;32(4):289-99.
Based on the five-year population study of red voles Clethrionomys rutilus Pallas in southern West Siberia, we analysed the distribution of two predominating species of parasites (tapeworms Hymenolepis horrida and immature instars of ticks Ixodes persulcatus) in different demographic groups of the host, and seasonal changes of their incidence in the population. We assessed primary humoral immune response of the voles (splenic antibody-forming cells) to antigenic challenge (injection of sheep erythrocytes) in respect to occurrence of these parasites. It was revealed that infection with H. horrida significantly reduced the numbers of antibody-forming cells in immature summer-born voles. In contrast, immune responses in immature and mature voles, which where parasitized by I. persulcatus at the moment of capture, were significantly higher as compared to non-infected hosts. The possible mechanisms of influence of parasites on variability of immune reactions of voles in the population under study are discussed.
基于对西西伯利亚南部红背田鼠（Clethrionomys rutilus Pallas）的五年种群研究，我们分析了两种主要寄生虫（绦虫Hymenolepis horrida和全沟硬蜱未成熟若虫Ixodes persulcatus）在宿主不同种群中的分布情况，以及它们在种群中的发病率的季节性变化。我们评估了田鼠（脾抗体形成细胞）针对这些寄生虫的存在对抗原刺激（注射绵羊红细胞）的主要体液免疫反应。结果显示，感染H. horrida显著减少了夏季出生的未成熟田鼠体内抗体形成细胞的数量。相比之下，在捕获时被全沟硬蜱寄生的未成熟和成熟田鼠的免疫反应，与未感染宿主相比显著更高。本文讨论了寄生虫对所研究种群中田鼠免疫反应变异性影响的可能机制。
