Guilmot J L, Diot E, Lasfargues G, Boissier C
Service de médecine interne B, CHU Bretonneau, Tours.
Rev Prat. 1998 Oct 1;48(15):1647-52.
Connective tissue diseases are the most important organic causes of Raynaud's phenomenon, and systemic sclerosis is the most frequent one. Careful history taking and clinical examination eventually lead to further investigations where capillaroscopy and specific autoantibodies tests have the best performances to reach diagnosis. Our understanding of local regulation of blood flow has been improved discovery of new neuromediators and local substances derived from endothelium. These compounds have direct implications for medical therapy and represent new hopes for the treatment of Raynaud's phenomenon which, however, remains difficult and incomplete for most patients.
结缔组织病是雷诺现象最重要的器质性病因，系统性硬化症最为常见。仔细的病史采集和临床检查最终会促使进行进一步的检查，其中毛细血管镜检查和特定自身抗体检测在明确诊断方面表现最佳。随着新的神经介质和内皮衍生的局部物质的发现，我们对局部血流调节的认识有所提高。这些化合物对药物治疗有直接影响，为雷诺现象的治疗带来了新希望，然而，对大多数患者来说，雷诺现象的治疗仍然困难且并不完善。
