Egri-Okwaji M T, Iroha E O, Kesah C N, Odugbemi T O
Department of Paediatrics, Lagos University Teaching Hospital, Nigeria.
West Afr J Med. 1998 Jul-Sep;17(3):136-9.
105 consecutively admitted neonates with tetanus were screened for sepsis to determine the prevalence of sepsis in neonatal Tetanus (NNT) patients and identify the bacterial pathogens causing septicaemia in them. The presence of omphalitis, poor colour, hypothermia and hyperthermia were found to be sensitive predictors of septicaemia in NNT patients. 50 bacterial pathogens were isolated from 50 babies. Klebsiella pneumoniae (20.7%), and Enterobacter cloacae (19.0%) were the leading gram negatives, while staphylococcus aureus (19.2%) was the prevalent gram positive organism isolated. Antimicrobial susceptibility profile heavily favours ofloxacin but a combination of cloxacillin and gentamicin is recommended as first line. Ceftazidime with about 60% susceptibility across board is the favoured cephalosporin.
对105例连续收治的破伤风新生儿进行败血症筛查，以确定新生儿破伤风（NNT）患者败血症的患病率，并确定导致其败血症的细菌病原体。发现脐炎、肤色不佳、体温过低和体温过高是NNT患者败血症的敏感预测指标。从50名婴儿中分离出50种细菌病原体。肺炎克雷伯菌（20.7%）和阴沟肠杆菌（19.0%）是主要的革兰氏阴性菌，而金黄色葡萄球菌（19.2%）是分离出的最常见革兰氏阳性菌。抗菌药物敏感性分析显示氧氟沙星占优势，但推荐氯唑西林和庆大霉素联合作为一线用药。头孢他啶总体敏感性约为60%，是最受欢迎的头孢菌素。
