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Anti-beta2-glycoprotein I antibodies.

作者信息

Tsutsumi A, Ichikawa K, Matsuura E, Koike T

机构信息

Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

Lupus. 1998;7 Suppl 2:S98-102.

PMID:9814683
Abstract

The relationship between presence of anti-beta2-glycoprotein I autoantibodies (abeta2-GPI) and history of thrombosis is now widely known. However, differences in the methodology of abeta2-GPI detection have made the comparison of data from different laboratories extremely difficult. We discuss the significance of abeta2-GPI of the IgG, IgM and IgA isotypes, and our approach to developing an easier and more reproducible method for the detection of this autoantibody. In addition, we present data that shows that commercially available enzyme immunoassay plates differ regarding detectability of abeta2-GPI. Since the clinical significance of this heterogeneity is presently unclear, the set-up of the detection systems and interpretation of data need great care.

摘要

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EJIFCC. 2010 Jan 26;20(4):151-8. eCollection 2010 Jan.