Kitchen S G, Zack J A
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095-1678, USA.
AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S235-9.
The pathogenesis of human immunodeficiency virus (HIV) in the lymphoid compartment has a dramatic effect on disease progression and important implications for therapeutic and vaccine strategies. Here we discuss current understanding of the pathogenesis of HIV in the lymphoid tissue. Various model systems that allow examination of the effect of retroviral infection in primary lymphoid organs are discussed, as well as current progress made with the use of these systems, with particular emphasis on the SCID-hu mouse.
人类免疫缺陷病毒（HIV）在淋巴组织中的发病机制对疾病进展具有显著影响，并对治疗和疫苗策略具有重要意义。在此，我们讨论目前对HIV在淋巴组织中发病机制的理解。我们将探讨各种可用于研究逆转录病毒感染对初级淋巴器官影响的模型系统，以及使用这些系统所取得的最新进展，尤其着重于SCID-hu小鼠。
