Blair C S, Davidson F, Lycett C, McDonald D M, Haydon G H, Yap P L, Hayes P C, Simmonds P, Gillon J
Departments of Medicine, and Medical Microbiology, University of Edinburgh, United Kingdom.
J Infect Dis. 1998 Dec;178(6):1779-82. doi: 10.1086/314508.
The prevalence, incidence, clinical features, and natural history of hepatitis G virus (HGV) or GB virus C (GBV-C) were investigated in a non-remunerated blood donor population to determine its clinical significance and its impact on blood safety. Of 1020 regular blood donors, 23 (2.25%) were positive for plasma HGV/GBV-C RNA. Alanine aminotransferase levels were lower than in uninfected donors (median, 20 IU/mL; 32 IU/mL in controls; P=.015). Clinical examination produced no other evidence for hepatitis or for shared nonhepatic diseases. Fifteen of 17 donors excreted HGV/GBV-C in saliva (mean level, 8x103 copies of RNA/mL). Testing of previous donations indicated an incidence of 170-200 new infections with HGV/GBV-C per 100,000 donor-years. The absence of further clinicopathologic data and the limitations of current polymerase chain reaction-based methods for screening suggests that it is neither necessary nor practical to commence screening.
在无偿献血人群中对庚型肝炎病毒（HGV）或GB病毒C（GBV-C）的流行率、发病率、临床特征及自然史进行了调查，以确定其临床意义及其对血液安全的影响。在1020名定期献血者中，23人（2.25%）血浆HGV/GBV-C RNA呈阳性。丙氨酸转氨酶水平低于未感染的献血者（中位数为20 IU/mL；对照组为32 IU/mL；P = 0.015）。临床检查未发现肝炎或其他非肝脏共患疾病的其他证据。17名献血者中有15人唾液中排出HGV/GBV-C（平均水平为每毫升8×10³份RNA拷贝）。对既往献血检测表明，每100,000献血者年HGV/GBV-C新感染率为170 - 200例。缺乏进一步的临床病理数据以及当前基于聚合酶链反应的筛查方法的局限性表明，开始筛查既无必要也不实际。
