Dunn C D
Aviat Space Environ Med. 1978 Aug;49(8):990-3.
Mice deprived of water for 24 h showed an increase in hematocrit and loss of body weight comparable to that seen in men during space flight. The increase in hematocrit was entirely due to a decrease in plasma volume and was associated with suppression of erythropoiesis, but with no significant change in the serum titer of a presumptive humoral regulator of erythropoiesis, Erythroid Stimulating Activity (ESA). Mice deprived of water for 24 h may be a useful model for the study of the early hematological effects of space flight. The suppression of erythropoiesis due to a relative erythrocytosis appears to be independent of ESA.
缺水24小时的小鼠出现了血细胞比容增加和体重减轻，这与男性在太空飞行期间的情况相当。血细胞比容的增加完全是由于血浆量减少，并且与红细胞生成受到抑制有关，但促红细胞生成的假定体液调节因子——红细胞刺激活性（ESA）的血清滴度没有显著变化。缺水24小时的小鼠可能是研究太空飞行早期血液学影响的有用模型。由于相对性红细胞增多导致的红细胞生成抑制似乎与ESA无关。
