Dunn C D, Lange R D
The Department of Medical Biology, The University of Tennessee Memorial Research Center, Knoxville, TN 37920, USA.
Acta Astronaut. 1979 May-Jun;6(5-6):725-32. doi: 10.1016/0094-5765(79)90029-8.
Various factors which are important in the regulation of erythropoiesis have been studied in dehydrated mice in the belief that some information would be gained relevant to the erythropoietic effects of space flight. Dehydration reduced the plasma volume and, because changes in red cell volume were minimal, the hematocrit was elevated. Thus a state of relative erythrocytosis was produced. Our understanding of the mechanism whereby these changes decreased red cell production is uncertain and appears to differ somewhat from the erythroid suppression seen following elevation of the hematocrit in animals with an absolute erythrocytosis. It is suggested that factors outside of the normal erythropoietic control pathway (such as energy balance) may play an important role in the decrease in red cell volume seen in man following space flight.
人们对脱水小鼠中各种对红细胞生成调节至关重要的因素进行了研究，认为可以获得一些与太空飞行对红细胞生成影响相关的信息。脱水使血浆量减少，并且由于红细胞体积变化极小，血细胞比容升高。因此产生了相对红细胞增多的状态。我们对这些变化减少红细胞生成的机制尚不确定，而且似乎与真性红细胞增多动物中血细胞比容升高后出现的红系抑制有所不同。有人提出，正常红细胞生成控制途径之外的因素（如能量平衡）可能在太空飞行后人体红细胞体积减少中起重要作用。
