Dunn C D
Am J Physiol. 1980 May;238(5):R301-5. doi: 10.1152/ajpregu.1980.238.5.R301.
Dehydrated mice showed a negative energy balance and hemoconcentration similar to that thought to occur in men during space flight, although the mechanism producing these changes may be completely different. The relative importance of dehydration and a negative energy balance in producing erythroid suppression has been investigated. The initial suppression appeared to be due to a reduced food intake. Thereafter, this negative energy balance produced about 40% of the erythroid suppression, the severity of which was augmented by dehydration. The decreased food consumption appeared to suppress erythropoiesis by reducing the sensitivity of the target cells in the spleen to erythropoietin (Ep), the erythropoietic hormone. Hemoconcentration decreased titers of Ep thus also suppressing erythropoiesis. Attempts to alleviate the effects of water deprivation and reduced food consumption by effects of water deprivation and reduced food consumption by water injections and the feeding of supplemented diets were only marginally effective at ameliorating the erythroid suppression. These studies indicate the importance of maintaining an adequate energy and fluid balance in the regulation of erythropoiesis.
脱水小鼠呈现出负能量平衡和血液浓缩，这与人们认为在太空飞行期间男性会出现的情况相似，尽管产生这些变化的机制可能完全不同。脱水和负能量平衡在导致红细胞生成受抑制方面的相对重要性已得到研究。最初的抑制似乎是由于食物摄入量减少所致。此后，这种负能量平衡导致了约40%的红细胞生成抑制，而脱水会加剧其严重程度。食物消耗减少似乎是通过降低脾脏中靶细胞对促红细胞生成素（Ep，一种红细胞生成激素）的敏感性来抑制红细胞生成。血液浓缩降低了Ep的效价，因此也抑制了红细胞生成。通过注水以及喂食补充饮食来试图减轻缺水和食物消耗减少的影响，在改善红细胞生成抑制方面仅取得了微弱的效果。这些研究表明，在红细胞生成的调节中维持充足的能量和液体平衡非常重要。
