Schaffer D L, Pendergrass H P
Radiology. 1976 Nov;121(2):431-4. doi: 10.1148/121.2.431.
Patients (219) with prostatic adenocarcinoma were classified on the basis of whether or not their bone scans were positive for metastasis. Acid and alkaline phosphatase determinations and clinical evaluations for bone metastases were reviewed. Of those with proved metastases, 43% had no bone pain, 39% had normal acid phosphatase levels, 23% normal alkaline phosphatase levels, 19% normal levels of both enzymes, and 15% normal enzyme levels without bone pain. Twenty-four per cent of the patients with normal enzyme levels and clinically unsuspected bone metastases had bone scans which proved positive for metastasis; 62% of these had normal radiographs.
219例前列腺腺癌患者根据其骨扫描是否有转移阳性进行分类。回顾了酸性和碱性磷酸酶测定以及骨转移的临床评估。在已证实有转移的患者中，43%无骨痛，39%酸性磷酸酶水平正常，23%碱性磷酸酶水平正常，19%两种酶水平均正常，15%酶水平正常且无骨痛。酶水平正常且临床上未怀疑有骨转移的患者中有24%骨扫描证实有转移阳性；其中62%X线片正常。
