Baldi A, Esposito V, De Luca A, Howard C M, Mazzarella G, Baldi F, Caputi M, Giordano A
Departments of Microbiology/Immunology and Pathology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Clin Cancer Res. 1996 Jul;2(7):1239-45.
The Rb (retinoblastoma) gene family is composed of three members: the RB gene (one of the best-studied tumor suppressor genes) and two related genes, p107 and pRb2/p130. These three proteins share many structural and functional features and play a fundamental role in growth control. Using immunocytochemical techniques, we evaluated a variety of lung tumor specimens for the expression of this family of proteins and compared protein expression with the histological grading of the tumors and with the expression of the proliferating cell nuclear antigen. These Rb family members displayed distinctive patterns when compared and contrasted using different parameters. The highest percentage of undetectable levels in all of the specimens examined and the tightest inverse correlation (P) with the histological grading and with proliferating cell nuclear antigen expression in the most aggressive tumor types were found for pRb2/p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
视网膜母细胞瘤（Rb）基因家族由三个成员组成：RB基因（研究最为深入的肿瘤抑制基因之一）以及两个相关基因，即p107和pRb2/p130。这三种蛋白质具有许多结构和功能特征，在生长控制中发挥着重要作用。我们运用免疫细胞化学技术，评估了多种肺肿瘤标本中该蛋白家族的表达情况，并将蛋白表达与肿瘤的组织学分级以及增殖细胞核抗原的表达进行了比较。当使用不同参数进行比较和对比时，这些Rb家族成员呈现出独特的模式。在所有检测的标本中，pRb2/p130的未检测到水平的比例最高，并且在最具侵袭性的肿瘤类型中，其与组织学分级以及增殖细胞核抗原表达的负相关性最为紧密（P值），这可能表明该蛋白在肺癌的发病机制和进展中发挥着重要作用。
